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Susan S. Taylor

From Wikipedia, the free encyclopedia
For the editor and journalist, see Susan L. Taylor.
Susan S. Taylor
Born1942 (age 81–82)
Racine, Wisconsin, US
EducationUniversity of Wisconsin, Johns Hopkins University
Known forStudies of protein kinase A, including the first kinase crystal structure
Awards
Scientific career
FieldsBiochemistry
InstitutionsUniversity of California, San Diego

Susan Taylor (born 1942[1]) is an American biochemist who is a Professor of Chemistry and Biochemistry and a Professor of Pharmacology at the University of California, San Diego. She is known for her research on protein kinases, particularly protein kinase A.[2] She was elected to the Institute of Medicine and the United States National Academy of Sciences in 1996.[3][4]

Early life and education

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Taylor was born in 1942 in Racine, Wisconsin.[1] She attended the University of Wisconsin as an undergraduate and received a B.A. in biochemistry in 1964. Despite originally planning for a career as a medical doctor, she received her PhD in physiological chemistry from Johns Hopkins University in 1968 and then worked as a postdoctoral fellow at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England, where she has said she settled on a career in research science.[5] After returning to the United States, she worked as a postdoc at the University of California, San Diego.[1][2]

Academic career

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After a brief postdoc position at UCSD, Taylor joined the faculty there in the Department of Chemistry and Biochemistry in 1972 and became a full professor in 1985.[1] She was a Howard Hughes Medical Institute Investigator from 1997 to 2014.[6]

Taylor served on the editorial board of the Journal of Biological Chemistry from 1985-1990 and served a term as the president of the American Society for Biochemistry and Molecular Biology in 1995.[2]

Research

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Taylor's research group has focused on the structure and function of protein kinases, particularly protein kinase A, since shortly after she began her independent research career.[1] Her group, collaborating with Janusz Sowadski, was the first to solve the crystal structure of a protein kinase when they reported the structure of PKA in 1991.[7] The group has subsequently published a number of papers on the dynamics and mechanism of PKA, or cyclic AMP-dependent protein kinase.[8][9][10]

Awards and honors

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References

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  1. ^ a b c d e "1995 - Susan Taylor". ASBMB Past Presidents. ASBMB. Retrieved 14 March 2016.
  2. ^ a b c d e f g h Taylor, Susan. "Taylor, Susan". UCSD Faculty Profiles. UCSD. Retrieved 14 March 2016.
  3. ^ a b "Susan S. Taylor". National Academy of Sciences. Retrieved 14 March 2016.
  4. ^ a b "IOM Member- Susan S. Taylor, Ph.D." Institute of Medicine. Retrieved 14 March 2016.
  5. ^ "Susan S. Taylor". Chemical Heritage Foundation. Archived from the original on July 12, 2016.
  6. ^ "Susan S. Taylor". Howard Hughes Medical Institute. Retrieved 14 March 2016.
  7. ^ Knighton, DR; Zheng, JH; Ten Eyck, LF; Ashford, VA; Xuong, NH; Taylor, SS; Sowadski, JM (26 July 1991). "Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science. 253 (5018): 407–14. doi:10.1126/science.1862342. PMID 1862342.
  8. ^ Taylor, SS; Yang, J; Wu, J; Haste, NM; Radzio-Andzelm, E; Anand, G (11 March 2004). "PKA: a portrait of protein kinase dynamics". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1697 (1–2): 259–69. doi:10.1016/j.bbapap.2003.11.029. PMID 15023366.
  9. ^ Kim, C; Xuong, NH; Taylor, SS (4 February 2005). "Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA". Science. 307 (5710): 690–6. doi:10.1126/science.1104607. PMID 15692043. S2CID 32156686.
  10. ^ Zhang, P; Smith-Nguyen, EV; Keshwani, MM; Deal, MS; Kornev, AP; Taylor, SS (10 February 2012). "Structure and allostery of the PKA RIIβ tetrameric holoenzyme". Science. 335 (6069): 712–6. doi:10.1126/science.1213979. PMC 3985767. PMID 22323819.
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